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The Progenitor virus (also known as the Clay virus) was a unique mutagenic retrovirus, a type of RNA virus discovered from a rare flower in West Africa. It possessed the ability to parasitize a host at a cellular level and mutate DNA and recombine genes, thereby strengthening a host's characteristics but causing detrimental mutations when cells developed abnormally. It was unknown to most of human civilization until its discovery by the founders of the Umbrella Corporation, who kept its existence top-secret and applied it to "B.O.W. (Bio Organic Weapons)" development, living biological weapons for military application.

The Proto Tyrant (T-001 Type) was the first prototype model of the "Tyrant" B.O.W. (Bio Organic Weapon) series developed by the Umbrella Corporation. It was a failed prototype but provided data instrumental to the later success of the Tyrant (T-002 Type).

Lord Oswell E. Spencer was a virologist and prideful multimillionaire aristocrat with absolute power as the world famous Chairman and CEO of the Umbrella Corporation.

As one of the company's three founders, he took part in the search that led to the discovery of the Progenitor virus. A cold, ruthless and ambitious individual with a god complex, he mercilessly murdered his rivals and gradually increased his power within the company. His hobbies were hunting and art collecting. 1

Raccoon City was an urban community located in the American mid-west. At its peak, it had a population of over one hundred thousand. While existing as a town initially, it was thanks to the many donations by Umbrella that Raccoon prospered into a full fledged city in the late 20th century. Following the T-virus outbreak that afflicted the city in September 1998, the entire community was destroyed by an experimental nuclear weapon by the United States government, as part of Mission Code: XX (Bacillus Terminate).